Author

T. Kunchok

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 7 Research Focus:metabolism & bioenergetics· 5 Research Focus:cell type annotation· 3 Assay:metabolomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. A. Lewis· 6 shared M. G. Vander Heiden· 4 shared S. H. Chan· 4 shared A. Muir· 3 shared K. L. Abbott· 3 shared A. Ali· 2 shared B. T. Do· 2 shared C. B. Clish· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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6 shared papersCancer Biology

C. A. Lewis

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

K. L. Abbott, A. Ali, B. I. Reinfeld, A. A. I. Deik, S. Subudhi, M. D. Landis, R. A. Hongo, K. L. Young, T. Kunchok, C. S. Nabel, K. D. Crowder, J. R. Kent, M. L. L. Madariaga, R. K. Jain, K. E. Beckermann, , M. G. Vander Heiden

This study profiles metabolites in renal cell carcinoma tissue and fluid to show that nutrient availability is more influenced by tissue-specific factors than tumor-driven changes.

bioRxiv · Dec 24, 2023Cancer Biology

Screening in serum-derived medium reveals differential response to compounds targeting metabolism

K. L. Abbott, A. Ali, D. Casalena, B. T. Do, R. Ferreira, J. H. Cheah, C. K. Soule, A. Deik, T. Kunchok, D. R. Schmidt, S. Renner, S. E. Honeder, M. Wu, S. H. Chan, T. Tseyang, , M. G. Vander Heiden

The paper screens compounds targeting metabolism in serum-derived medium to identify differential responses in cancer cells, aiming to improve drug response prediction.

bioRxiv · Feb 25, 2023Cancer Biology

MMD scaffolds ACSL4 and MBOAT7 to promote polyunsaturated phospholipid synthesis and susceptibility to ferroptosis

V. V. Phadnis, J. Snider, V. Wong, K. D. Vaccaro, T. Kunchok, J. Allen, Z. Yao, B. Geng, K. Weiskopf, I. Stagljar, W. S. Henry, R. A. Weinberg

This paper identifies MMD as a scaffold protein that promotes ferroptosis by facilitating the synthesis of arachidonoyl-phospholipids through interactions with ACSL4 and MBOAT7.

bioRxiv · Sep 1, 2022Cell Biology

Cancer tissue of origin constrains the growth and metabolism of metastases

S. Sivanand, Y. Gultekin, P. Winter, S. Y. Vermeulen, K. Tchourine, K. L. Abbott, L. V. Danai, F. Gourgue, B. T. Do, K. Crowder, T. Kunchok, A. N. Lau, A. M. Darnell, A. Jefferson, S. Morita, , M. G. Vander Heiden

This study shows that cancer tissue-of-origin influences the metabolism and growth preferences of both primary and metastatic tumors.

bioRxiv · Aug 17, 2022Cancer Biology

Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction

K. J. Condon, J. M. Orozco, C. H. Adelmann, J. B. Spinelli, P. W. van der Helm, J. M. Roberts, T. Kunchok, D. M. Sabatini

This study uses CRISPR screens to identify genes regulating mTORC1 activity and reveals that mitochondrial dysfunction is sensed through AMPK and HRI signaling pathways.

bioRxiv · Oct 22, 2020Cell Biology

MCART1 is required for mitochondrial NAD transport

N. Kory, J. uit de Bos, S. van der Rijt, N. Jankovic, M. Guera, N. Arp, I. A. Pena, G. Prakash, S. H. Chan, T. Kunchok, C. A. Lewis, D. M. Sabatini

The paper identifies MCART1 as a mitochondrial NAD+ transporter in human cells by showing its essentiality with ETC components and its effect on NAD levels and mitochondrial function.

bioRxiv · Aug 28, 2020 · PreprintCell Biology

Dihydroxyacetone phosphate signals glucose availability to mTORC1

J. M. Orozco, P. A. Krawczyk, S. M. Scaria, A. L. Cangelosi, S. H. Chan, T. Kunchok, C. A. Lewis, D. Sabatini

This study identifies dihydroxyacetone phosphate (DHAP) as the glucose-derived metabolite that activates mTORC1, linking glucose availability to cell growth regulation.

bioRxiv · Jun 21, 2020Cell Biology

Quantification of microenvironmental metabolites in murine cancer models reveals determinants of tumor nutrient availability

M. R. Sullivan, L. V. Danai, C. A. Lewis, S. H. Chan, D. Y. Gui, T. Kunchok, E. A. Dennstedt, M. G. Vander Heiden, A. Muir

The paper quantifies microenvironmental metabolites in murine cancer models and identifies factors affecting tumor nutrient availability.

bioRxiv · Jan 3, 2019Cancer Biology