Author

J. Mark Brown

Cleveland Clinic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:metabolomics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Amy C BurrowsiD· 2 shared Anthony J. HorakiD· 2 shared Adam E. MullickiD· 1 shared Amanda L. BrowniD· 1 shared Chase K. A. NeumanniD· 1 shared Chelsea Finney· 1 shared Daniel Ferguson· 1 shared Daniel J. SilveriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

Amy C BurrowsORCID

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Author profile →

2 papers

Recent·Most cited

Per-and polyfluoroalkyl substances (PFAS) driven reorganization of brain metabolism is impacted by resident microbiota

Xiayan Ye, Amy C Burrows, Anthony J. Horak, Zeneng Wang, Elijah Obringer, Katherine Roth, Michael C. Petriello, J. Mark Brown

This study shows that gut microbiota modulates PFAS-induced metabolic changes in the brain across different regions and tissues.

bioRxiv · Aug 7, 2026 · PreprintMicrobiology

The Lipid Hydrolase ABHD6 is a Therapeutic Target in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)-Related Hepatocellular Carcinoma

Danny Orabi, William J. Massey, Kevin K. Fung, Venkateshwari Varadharajan, Iyappan Ramachandiran, Rakhee Banerjee, Daniel J. Silver, Lucas J. Osborn, Amanda L. Brown, Stephanie Marshall, Daniel Ferguson, Shijie Cao, Rebecca C. Schugar, Chelsea Finney, Chase K. A. Neumann, , J. Mark Brown

This study identifies ABHD6 as a therapeutic target in MASLD-related HCC by showing its role in lysosomal lipid remodeling and tumor progression.

bioRxiv · Jul 29, 2025 · PreprintCancer Biology