Daniel J. Silver

This study shows that platelet PAR4 signaling, interacting with estrogen receptor beta, drives glioblastoma progression and immune suppression, with sex-specific effects on survival and TME dynamics.

This study shows that Cx43 promotes glioblastoma cancer stem cell survival and self-renewal via a WNK1-c-MYC signaling pathway.

This study identifies ABHD6 as a therapeutic target in MASLD-related HCC by showing its role in lysosomal lipid remodeling and tumor progression.

This study shows that spermidine, a metabolite from glioblastoma cells, suppresses CD8+ T cell function, promoting tumor growth and poor patient outcomes.

This study shows that intestinal stem cells (ISCs) enhance local mucosal immunity by engulfing apoptotic bodies, which leads to increased T cell activity through TNF signaling.

This study shows that blocking CSPG production and the receptor PTPσ improves functional recovery in chronic spinal cord injury models.