Dissecting the Determinants of Domain Insertion Tolerance and Allostery in Proteins
J. Mathony, S. Aschenbrenner, P. Becker, D. Niopek
The paper systematically assesses domain insertion permissibility in proteins and identifies sequence conservation as a key determinant, enabling the design of switchable protein hybrids.
bioRxiv · Apr 11, 2023Bioengineering