New AAV9 engineered variants with enhanced neurotropism and reduced liver off-targeting in mice and marmosets
S. G. Giannelli, M. Luoni, B. Bellinazzi, A. Iannielli, J. Middeldorp, I. Philippens, J. Korbelin, V. Broccoli
This study develops two new AAV9 variants with improved brain targeting and reduced liver off-targeting by modifying the galactose-binding domain and displaying peptides.
bioRxiv · Jun 27, 2023Bioengineering