BioengineeringbioRxiv
New AAV9 engineered variants with enhanced neurotropism and reduced liver off-targeting in mice and marmosets
S. G. Giannelli, M. Luoni, B. Bellinazzi…·V. Broccoli
This study develops two new AAV9 variants with improved brain targeting and reduced liver off-targeting by modifying the galactose-binding domain and displaying peptides.
DOI 10.1016/j.isci.2024.109777