Immune signatures of common exposures through co-occurrence of T-cell receptors in tens of thousands of donors
D. H. May, S. Woodhouse, M. T. Noakes, K. Doroschak, R. Elyanow, A. Moore, E. Osborne, B. Greenfield, T. Hayes, R. Taniguchi, Z. Yang, J. Grino, R. Byron, J. Oaks, A. Sherwood, , H. S. Robins
The paper identifies immune exposure signatures by clustering T-cell receptors co-occurring across donors, linking them to specific pathogens and HLA alleles.
bioRxiv · Mar 26, 2024Immunology