A. Moore

An α-1,3-fucosyltransferase influences thermal nocifensive escape behaviors in Drosophila larvae

This study identifies a mutation in the FucTA gene affecting thermal nocifensive escape behaviors in Drosophila larvae.

Biological and Genetic Determinants of Glycolysis: Phosphofructokinase Isoforms Boost Energy Status of Stored Red Blood Cells and Transfusion Outcomes

The paper identifies genetic polymorphisms and metabolite levels in stored red blood cells that correlate with hemolysis and transfusion outcomes.

Immune signatures of common exposures through co-occurrence of T-cell receptors in tens of thousands of donors

The paper identifies immune exposure signatures by clustering T-cell receptors co-occurring across donors, linking them to specific pathogens and HLA alleles.

Analytical code sharing practices in biomedical research

This study analyzes code sharing practices in biomedical research and finds that less than half of manuscripts share analytical code, with significant associations between code availability statements and actual code sharing.

A computational model of Pseudomonas syringae metabolism unveils the role of branched-chain amino acids in virulence expression at the early stages of Arabidopsis colonization

This study uses a computational model to show that branched-chain amino acids suppress virulence in Pseudomonas syringae during early plant infection.

Genome-wide metabolite quantitative trait loci analysis (mQTL) in red blood cells from volunteer blood donors

The paper identifies 423 genetic loci associated with 132 metabolites in red blood cells using a genome-wide association study of volunteer blood donors.

Latent human herpesvirus 6 is reactivated in chimeric antigen receptor T cells

The paper identifies HHV-6 reactivation in CAR T cells using single-cell sequencing and links it to clinical neurotoxicity observed in patients.

Unlocking the microblogging potential for science and medicine

The paper analyzes Twitter activity of 6,000 biomedical scientists, finding gender differences in tweeting behavior and engagement patterns.

Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drive rapid and potent immunogenicity capable of single-dose protection

This study develops glycan-modified SARS-CoV-2 nanoparticle vaccines that induce potent neutralizing antibodies and single-dose protection against SARS-CoV-2 in multiple animal models.

NOTCH1 drives immune-escape mechanisms in B cell malignancies

This study shows NOTCH1 mutations in B cell malignancies promote immune escape by upregulating PD-L1 and silencing HLA-class II, leading to poor clinical outcomes.

Genomic Background Governs Opposing Responses to Nalidixic Acid Upon Megaplasmid Acquisition in Pseudomonas

The paper shows that acquiring a megaplasmid can either sensitize or increase resistance to nalidixic acid in different Pseudomonas strains, depending on their genomic background.

Proteomics characterisation of the L929 cell supernatant and its role in BMDM differentiation

The paper characterizes L929 cell supernatant proteome and shows it induces a stronger anti-inflammatory M1 phenotype in BMDMs compared to M-CSF alone.

Detection of SARS-CoV-2 RNA by multiplex RT-qPCR

This paper develops a multiplex RT-qPCR assay for SARS-CoV-2 detection that uses existing primer/probe sets and reduces reagents, costs, time, and labor compared to singleplex assays.

Abuse liability, antinociceptive, and discriminative stimulus properties of IBNtxA

This study evaluates the analgesic, rewarding, and discriminative stimulus properties of IBNtxA, finding it produces potent antinociception with low abuse liability due to κ agonist effects.

Physiotherapist and Podiatrist Independent Prescribing in the United Kingdom: A quasi experimental study

This study compares patient outcomes between physiotherapist and podiatrist independent prescribers and non-prescribers, finding similar quality of life and satisfaction but higher resource use for prescribers.

Growth Cone-Localized Microtubule Organizing Center Establishes Microtubule Orientation in Dendrites

The paper identifies a non-centrosomal microtubule organizing center in dendritic growth cones that establishes microtubule orientation, with perturbation causing reversed polarity.

Old fibroblasts secrete inflammatory cytokines that drive variability in reprogramming efficiency and may affect wound healing between old individuals

This study shows that old fibroblasts secrete inflammatory cytokines, leading to variability in reprogramming efficiency and affecting wound healing in older individuals.

Targeted Enrichment of Large Gene Families for Phylogenetic Inference: Phylogeny and Molecular Evolution of Photosynthesis Genes in the Portullugo (Caryophyllales)

The paper demonstrates the feasibility of including large gene families in hybrid enrichment protocols for phylogenetic analysis, revealing adaptive amino acid substitutions in C4 and CAM photosynthesis genes.

Synthesis-Free PET Imaging Of Brown Adipose Tissue And TSPO Via Combination Of Disulfiram And 64CuCl2

This paper demonstrates a synthesis-free PET imaging method for brown adipose tissue and TSPO using Disulfiram and 64CuCl2, showing TSPO as a biomarker for BAT mass.