Z. Yang

Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target

This study integrates multi-omic data from lung cancer and brain metastases to identify mitochondrial metabolism as a therapeutic target in brain metastases.

Association study of Plasmodium falciparum Acetyl-CoA Synthetase Mutations S868G and V949I with antimalarial drugs

This study investigates the association of PfACAS mutations S868G and V949I with antimalarial drug resistance using whole-genome sequencing and CRISPR/Cas9-engineered parasites.

Targeting NOTCH2-JAG1 juxtacrine signaling reverses macrophage-mediated tumor resistance to taxol

This study identifies NOTCH2-JAG1 juxtacrine signaling as a target to reverse macrophage-mediated taxane resistance in ovarian cancer by sensitizing tumors to paclitaxel.

Fluorogenic Aptamer Optimizations on a Massively Parallel Sequencing Platform

This paper optimizes a DNA-based fluorogenic aptamer (D-FAP) using a screening-and-simulation pipeline on a repurposed sequencing platform, achieving improved fluorescence properties.

Early-life Microbiome-Derived HCA Enhances Type 3 Immunity via FXR-dependent m6A RNA methylation

Role of vaccinia virus growth factor in stimulating the mTORC1-CAD axis of the de novo pyrimidine pathway under different nutritional cues

This study identifies vaccinia virus growth factor (VGF) as a key factor enabling mTORC1-CAD axis activation in nutrient-poor conditions, enhancing de novo pyrimidine synthesis for viral replication.

Lydicamycins Induce Morphological Differentiation in Actinobacterial Interactions

This study identifies lydicamycins as inducers of morphological differentiation in actinobacterial interactions using co-cultivation and multi-omics approaches.

CCDC32 stabilizes clathrin-coated pits and drives their invagination

This study identifies CCDC32 as an endocytic accessory protein that stabilizes clathrin-coated pits and drives their invagination, with mutations linked to cardio-facio-neuro-developmental syndrome.

PIN2-mediated self-organizing transient auxin flow contributes to auxin maxima at the tip of Arabidopsis cotyledons

The paper shows that PIN2-mediated transient auxin flow creates auxin maxima at Arabidopsis cotyledon tips, coordinating pavement cell interdigitation.

Hierarchical global and local auxin signals coordinate cellular interdigitation in Arabidopsis

The paper shows auxin signaling coordinates cell shape in Arabidopsis through global and local pathways involving TIR1/AFB and TMK.

Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

This study identifies ADGRA3 as a GPCR that promotes adipose thermogenesis through constitutive activity and the Gs-PKA-CREB axis, with hesperetin as a potential agonist for therapeutic obesity treatment.

Acetyl-CoA Synthetase Mutations S868G and V949I Do Not Confer Resistance to Antimalarial Drugs in vitro in Plasmodium falciparum.

This study investigates whether mutations in PfACAS confer antimalarial drug resistance by engineering parasite lines with these mutations and testing their drug susceptibility in vitro.

Stearoyl coenzyme A desaturase 1 (SCD1) regulates foot-and-mouth disease virus replication by modulating host cell lipid metabolism and 2C-mediated replication complex formation

This study shows SCD1 regulates FMDV replication by modulating lipid metabolism and 2C-mediated replication complex formation, suggesting it as a potential drug target for positive-sense RNA viruses.

Pseudomonas syringae socially-induced swimming motility requires the molybdenum cofactor

The paper identifies molybdenum cofactor as essential for socially-induced swimming motility in Pseudomonas syringae during baited expansion behavior.

A foundation model for generalizable cancer diagnosis and survival prediction from histopathological images

This paper introduces BEPH, a lightweight foundation model for cancer diagnosis and survival prediction from histopathological images, showing improved performance over existing models with limited data.

In Search of the Perfect Model: How Cancer Cell Lines Relate to Native Cancers

This study compares cancer cell lines to native cancers using CNV profiles and ML to identify cell lines that best represent specific cancer types.

Inference of continuous gene flow between species under misspecified models

This study investigates biases in inferring gene flow between species under misspecified models and finds that pulse introgression models are more robust to model misspecification than continuous migration models.

Neutraceuticals silybin B, resveratrol and epigallocatechin-3 gallate (EGCG) bind to troponin to restore the loss of lusitropy caused by cardiomyopathy mutations in vitro, in vivo, and in silico

Therapeutic Targeting of TIM-4-L With Engineered T Cells for Acute Myeloid Leukemia

This study identifies TIM-4-L as a novel target for T cell therapy in AML, showing engineered T cells effectively eliminate AML cells in vitro and in vivo.

CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

This study identifies convergent therapeutic targets for chemoresistance in cancer using CRISPR screens across multiple drug conditions and cancer models.

Ligand efficacy shifts a nuclear receptor conformational ensemble between transcriptionally active and repressive states

This study identifies a PPARγ ligand series that shifts the receptor's conformational ensemble between active and repressive states, revealing how subtle chemical changes influence its function.

Alligamycin A, an unprecedented antifungal β-lactone spiroketal macrolide from Streptomyces iranensis

This paper identifies alligamycin A, a novel antifungal compound from Streptomyces iranensis, and demonstrates its potent antifungal activity against clinically relevant fungi.

Immune signatures of common exposures through co-occurrence of T-cell receptors in tens of thousands of donors

The paper identifies immune exposure signatures by clustering T-cell receptors co-occurring across donors, linking them to specific pathogens and HLA alleles.

Design and Evaluation of Nanoscale Materials with Programmed Responsivity towards Epigenetic Enzymes

This paper designs and evaluates nanomaterials that disassemble in response to HDAC enzymes, revealing a mechanism based on deacetylation-induced amphiphilicity reduction.

Surface Hydrophilicity Promotes Bacterial Twitching Motility

This paper shows that bile salts and detergents enhance bacterial twitching motility by altering surface hydrophilicity, not by causing physiological stress.

Protein disulfide isomerase disassembles stress granules and blocks cytoplasmic aggregation of TDP-43 in ALS

This study shows that wild-type PDI disassembles stress granules and prevents TDP-43 mislocalization and aggregation in ALS, while abnormal PDI leads to amyloid fibrils and neuronal death.

A 10-valent composite mRNA vaccine against both influenza and COVID-19

This paper introduces FLUCOV-10, a 10-valent mRNA vaccine targeting influenza and SARS-CoV-2, showing robust immune responses and complete protection in mice against multiple strains.

FACS-Sortable Triple Emulsion Picoreactors for Screening Reactions in Biphasic Environments

This paper develops FACS-sortable triple emulsion picoreactors for high-throughput screening of biphasic reactions, demonstrating stability and compatibility with protein synthesis.

Stimulation Effects Mapping for Optimizing Coil Placement for Transcranial Magnetic Stimulation

This paper introduces a framework for optimal TMS coil placement without segmentation or meshing, validated across multiple datasets showing consistent results.

Arginine Di-methylation of RIPK3 Safeguards Necroptosis for Intestinal Homeostasis

This paper shows that arginine di-methylation of RIPK3 by PRMT5 prevents necroptosis in intestinal epithelial cells, maintaining homeostasis and preventing disease.