Author

J. Oroz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

D. Pantoja-Uceda· 2 shared D. V. Laurents· 2 shared E. J. Cabrita· 2 shared A. Gallardo-Orihuela· 1 shared A. J. Doig· 1 shared A. Pino-Angeles· 1 shared B. S. McAvan· 1 shared C. Fernandez· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

D. Pantoja-Uceda

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

NEK7 activates the NLRP1 Inflammasome

I. Muela-Zarzuela, A. Gallardo-Orihuela, A. Pino-Angeles, J. M. Suarez-Rivero, D. Boy-Ruiz, M. de Gregorio-Procopio, J. Oroz, G. Mbalaviele, M. D. Cordero

This study shows NEK7 activates NLRP1 inflammasome independently of NLRP3, affecting IL-1β maturation in Nek7-deficient cells.

bioRxiv · Dec 21, 2022 · PreprintImmunology

Fused in Sarcoma undergoes cold denaturation: implications on phase separation

S. Felix, D. V. Laurents, J. Oroz, E. J. Cabrita

This study shows that FUS globular domains undergo cold denaturation, promoting phase separation under cold stress conditions.

bioRxiv · Feb 8, 2022Biophysics

Glycine Rich Segments Adopt Polyproline II Helices Which May Contribute to Biomolecular Condensate Formation

M. Mompean, B. S. McAvan, S. S. Felix, M. Trevino, J. Oroz, D. Pantoja-Uceda, E. J. Cabrita, A. J. Doig, D. V. Laurents

The paper investigates whether Gly-rich segments of disordered proteins form polyproline II helices, which may contribute to biomolecular condensate stability.

bioRxiv · Jul 30, 2020 · PreprintBiophysics

Conformational Priming of RepA-WH1 for Functional Amyloid Conversion Detected by NMR Spectroscopy

D. Pantoja-Uceda, J. Oroz, C. Fernandez, E. de Alba, R. Giraldo, D. Laurents

This study uses NMR spectroscopy to investigate conformational changes in RepA-WH1 that enable its transition to an amyloid state, revealing the role of structural dynamics and ligand binding.

bioRxiv · Apr 17, 2019Biochemistry

Dynamic Aha1 Co-Chaperone Binding to Human Hsp90

J. Oroz, L. J. Blair, M. Zweckstetter

This study determines the solution structure of the Hsp90/Aha1 complex using NMR, revealing structural changes induced by Aha1 and a two-step binding mechanism.

bioRxiv · Feb 14, 2019Biophysics