Structure-guided design of a synthetic mimic of an EPCR-binding PfEMP1 protein
N. M. Barber, C. Lau, L. Turner, G. Watson, S. Thrane, J. P. A. Lusingu, T. Lavstsen, M. K. Higgins
The paper designs a synthetic PfEMP1 mimic using structural data to elicit antibodies against EPCR-binding PfEMP1, showing nanomolar affinity and cross-reactivity.
bioRxiv · Aug 28, 2019 · PreprintMicrobiology