C. Lau

Sharing Data from the Human Tumor Atlas Network through Standards, Infrastructure, and Community Engagement

The paper describes how the Human Tumor Atlas Network shares data through standards, infrastructure, and community engagement, making datasets accessible via multiple platforms.

Multivalent Exosome based protein vaccine: a "mix and match" approach to epidemic viruses' challenges.

This study develops a multivalent exosome-based vaccine platform that effectively induces strong immune responses against multiple viruses using minimal protein and no adjuvant.

The gag-like gene RTL8 antagonizes PEG10-mediated virus like particles

This study identifies RTL8 as an antagonist of PEG10-mediated virus-like particle formation in human cells.

Identifying Human Specific Adverse Outcome Pathways of Per- and Polyfluoroalkyl Substances Using Liver-Chimeric Humanized Mice

This study uses liver-chimeric humanized mice to identify human-specific adverse hepatic effects of PFAS, finding NR1D1 inhibition as a common molecular mechanism.

The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9

This study identifies the discontinuous quaternary neoepitope of the C9 protein in the complement C5b-9 complex using cryo-EM, revealing its formation through adjacent domains without major conformational changes.

DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells

This study identifies DLL4 and VCAM1 as critical factors enhancing T cell progenitor emergence from human pluripotent stem cells during the endothelial-to-hematopoietic transition.

First isolation of virulent Tenacibaculum maritimum strains from diseased orbicular batfish (Platax orbicularis) farmed in Tahiti Island

The study isolates virulent Tenacibaculum maritimum strains from diseased orbicular batfish in Tahiti, linking them to white-patch disease and identifying genetic diversity among isolates.

Structure-guided design of a synthetic mimic of an EPCR-binding PfEMP1 protein

The paper designs a synthetic PfEMP1 mimic using structural data to elicit antibodies against EPCR-binding PfEMP1, showing nanomolar affinity and cross-reactivity.