ATP Citrate Lyase Drives Vascular Remodeling Diseases Development Through Metabolic-Epigenetic Reprograming.
Y. Grobs, C. Romanet, S.-E. Lemay, A. Bourgeois, P. Voisine, C. Theberge, M. Sauvaget, S. Breuils-Bonnet, S. Martineau, R. El-kabbout, M. Mougin, E. Dumais, J. Perron, N. Flamand, F. Potus, , s. Bonnet
This study identifies ATP-citrate lyase as a driver of vascular remodeling in pulmonary hypertension and coronary artery disease, showing its inhibition can reverse pathological changes.
bioRxiv · Feb 2, 2024 · PreprintPhysiology