S. Bonnet

Exploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension: Insights from Comprehensive Multicenter Preclinical Studies

The study identifies integrin α5β1 as a key driver of pulmonary vascular remodeling in PAH and shows its inhibition improves hemodynamics and RV function in preclinical models.

RV-specific Targeting of Snai1 Rescues Pulmonary Hypertension-induced Right Ventricular Failure by Inhibiting EndMT and Fibrosis via LOXL2 Mediated Mechanism

This study shows that targeting Snai1 in the right ventricle rescues pulmonary hypertension-induced failure by reducing EndMT, fibrosis, and FMT through a LOXL2-dependent mechanism.

The SUMOylation inhibitor TAK-981 (Subasumstat) triggers IFN-I-dependent activation of Natural Killer cells against Acute Myeloid Leukemias.

This paper shows that TAK-981 activates NK cells against AML by inducing IFN-I secretion, enhancing their cytotoxicity and cytokine production.

ATP Citrate Lyase Drives Vascular Remodeling Diseases Development Through Metabolic-Epigenetic Reprograming.

This study identifies ATP-citrate lyase as a driver of vascular remodeling in pulmonary hypertension and coronary artery disease, showing its inhibition can reverse pathological changes.

RIP140 regulates HES1 oscillatory expression and mitogenic activity in colon cancer cells

This study shows RIP140 regulates HES1 expression and mitogenic activity in colon cancer cells, with implications for patient survival.

Massive export of diazotrophs across the tropical south Pacific Ocean

The paper quantifies diazotroph contribution to organic matter export in the South Pacific, showing they account for up to 100% of particulate nitrogen export fluxes.

Fine scale sampling unveils diazotroph patchiness in the South Pacific Ocean

The paper reveals diazotroph patchiness in the South Pacific Ocean at high resolution, showing different groups are influenced by fine-scale structures.

RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53

This study shows RIP140 inhibits breast cancer cell glycolysis and proliferation by reducing GLUT3 expression through interaction with HIF-2 and p53.