Degradation of Polycomb Repressive Complex 2 with an EED-targeted Bivalent Chemical Degrader
F. Potjewyd, A.-M. Turner, J. Beri, J. Rectenwald, J. Norris-Drouin, S. Cholensky, D. Margolis, K. Pearce, L. Herring, L. I. James
This paper introduces a bivalent chemical degrader, UNC6852, that targets PRC2 components and demonstrates its ability to degrade PRC2 and inhibit EZH2 activity in cancer cells.
bioRxiv · Jun 21, 2019Cancer Biology