Cancer BiologybioRxiv
Degradation of Polycomb Repressive Complex 2 with an EED-targeted Bivalent Chemical Degrader
F. Potjewyd, A.-M. Turner, J. Beri…·L. I. James
This paper introduces a bivalent chemical degrader, UNC6852, that targets PRC2 components and demonstrates its ability to degrade PRC2 and inhibit EZH2 activity in cancer cells.
DOI 10.1016/j.chembiol.2019.11.006