J. Rosenbauer

Development of a scoring function for comparing simulated and experimental tumor spheroids

This paper develops a data-agnostic method to compare spatial features of tumor spheroids by defining features and metrics, and applies it to experimental and simulated spheroids.

Mechanical influences on in silico tumor evolution

This paper uses computational modeling to show that mechanical fluctuations in nutrient supply can accelerate tumor evolution by favoring low-adhesion cells.

Emerging Tumor Development by Simulating Single-cell Events

This paper simulates the growth of mm-sized tumors composed of 1.5 million cells to study cancer development, resource competition, and treatment responses.