Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export
L. Duan, B. Zaepfel, V. Aksenova, M. Dasso, J. Rothstein, P. Kalab, L. R. Hayes
This study shows that TDP-43 nuclear localization depends on RNA binding to GU-rich intronic pre-mRNAs and is regulated by transcription and pre-mRNA processing.
bioRxiv · Aug 24, 2021Cell Biology