L. Duan

Molecular insights into atypical modes of beta-arrestin interaction with seven transmembrane receptors

This study presents cryo-EM structures and experimental data revealing how beta-arrestins interact with GPCRs, particularly those with phosphorylation in the third intracellular loop and intrinsically biased receptors.

Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation

This study shows that inhibiting PDHK reduces NLRP3 inflammasome activation in macrophages, decreasing inflammation and tissue damage.

Mechanical force induces DRP1-dependent asymmetrical mitochondrial fission for quality control

The paper shows mechanical force induces DRP1-dependent asymmetrical mitochondrial fission, leading to mtDNA-free fragments that recruit Parkin proteins.

Productive and latent HIV infections originate in resting CD4+ T cells

This study shows that resting CD4+ T cells are the initial source of both productive and latent HIV infections in the earliest stages of detectable infection.

Detecting sources of immune activation and viral rebound in HIV infection

The paper compares assays for detecting HIV-producing cells and p24 during ART to identify sources of immune activation and viral rebound.

Poly-glutamine-dependent self-association as a potential mechanism for regulation of androgen receptor activity

This study investigates how poly-glutamine sequences in the androgen receptor (AR) N-terminal domain influence its activity and interactions with KDM4A, suggesting a role for phase separation in regulating AR function in prostate cancer.

Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export

This study shows that TDP-43 nuclear localization depends on RNA binding to GU-rich intronic pre-mRNAs and is regulated by transcription and pre-mRNA processing.

13C tracer analysis identifies extensive recycling of endogenous CO2 in vivo

This study uses 13C tracing to show that endogenous CO2 recycling is significant in vivo, affecting isotopologue distribution and providing insights for metabolic studies.

Genome-wide screen of genomic imprinting in endosperm and population-level analysis reveal allelic variation for imprinting in flax

The paper identifies imprinted genes in flax endosperm and shows their role in intraspecific variation and domestication.

Divergence in a stress-associated gene regulatory network underlies differential growth control in the Brassicaceae family

The study identifies conserved and divergent ABA gene regulatory networks across Brassicaceae species, revealing how network structure influences growth control under stress.

Disruption of CYCLOPHILIN 38 function reveals a photosynthesis-dependent systemic signal controlling lateral root emergence

This study identifies CYP38 as a gene regulating lateral root emergence through photosynthesis-dependent signaling, revealing a role for auxin biosynthesis in this process.

The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development

The paper identifies Hhex and Tle3 as regulators of memory B cell differentiation through single-cell RNA-seq and CRISPR screening, showing their interaction and functional roles.

C9orf72 arginine-rich dipeptide repeat proteins disrupt importin β-mediated nuclear import

This study shows that C9orf72-derived arginine-rich dipeptide repeat proteins disrupt importin β-mediated nuclear import in neurons and HeLa cells, without causing NCT protein sequestration or FG-rich pore complex blockade.

E-cadherin binds glycosylated sodium-taurocholate cotransporting polypeptide to facilitate hepatitis B virus entry

This study identifies E-cadherin as a facilitator of HBV entry by interacting with glycosylated NTCP and regulating hepatocyte polarity.

Novel pipeline of high-frequency neoantigens heathy donor-based validation in breast cancer

The paper develops a computational pipeline to identify high-frequency neoantigens in breast cancer and validates their immunogenicity using healthy donor blood samples.

Clinical Significance of C4d Deposition in Renal Tissues from Patients with Primary Sj&oumlgren's Syndrome--A Preliminary Study

This study examines C4d deposition in renal tissues of primary Sjögren's syndrome patients, finding higher serum creatinine levels in those with tubulointerstitial C4d positivity.

Revealing The Cell-Material Interface With Nanometer Resolution By FIB-SEM

This paper introduces a method to visualize the cell-material interface at nanometer resolution using FIB-SEM, enabling detailed study of cell-material interactions.