M. Dasso

A Role for Nup153 in Nuclear Assembly Reveals Differential Requirements for Targeting of Nuclear Envelope Constituents

This study identifies Nup153's role in nuclear envelope formation, showing differential requirements for targeting of nuclear envelope proteins during nuclear reassembly.

Architecture of the cytoplasmic face of the nuclear pore

The paper establishes the near-atomic molecular architecture of the cytoplasmic face of the human nuclear pore complex using interdisciplinary methods.

Role of the Topoisomerase IIα Chromatin Tether domain in Nucleosome Binding & Chromosome Segregation

This study shows that TopoII's Chromatin Tether domain binds methylated histone H3K27me3 to prevent anaphase ultra-fine bridges, ensuring proper chromosome segregation.

Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export

This study shows that TDP-43 nuclear localization depends on RNA binding to GU-rich intronic pre-mRNAs and is regulated by transcription and pre-mRNA processing.

The Nuclear Pore Complex consists of two independent scaffolds

The paper investigates the structural roles of nucleoporins in the Nuclear Pore Complex (NPC) by degrading individual components and observing the effects on NPC domains.

PICH function is required for organization of SUMOylated proteins on mitotic chromosomes

This study shows PICH is required for organizing SUMOylated proteins on mitotic chromosomes, ensuring proper chromosome segregation through its DNA translocase activity and SUMO-binding ability.

PICH promotes SUMOylated TopoisomeraseIIα dissociation from mitotic centromeres for proper chromosome segregation

This study shows PICH promotes dissociation of SUMOylated TopoII from mitotic chromosomes, ensuring proper chromosome segregation.

Distinct Basket Nucleoporins roles in Nuclear Pore Function and Gene Expression: Tpr is an integral component of the TREX-2 mRNA export pathway