ADA2 is a lysosomal DNase regulating the type-I interferon response
O. K. Greiner-Tollersrud, M. Krausz, E. Bartok, V. Boehler, H. Ebersbach, S. Baash, D. Guerini, G. Hartmann, K. Huebscher, G. Kochs, M. Marchant, A. Polyzou, J. Schepp, M. Seidl, C. R. Smulski, , M. Proietti
The paper identifies ADA2 as a lysosomal DNase that regulates the type-I interferon response by degrading cGAS/Sting-activating ligands in DADA2 patients.
bioRxiv · Jun 21, 2020 · PreprintImmunology