HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression
J. Schloss, R. Ali, J. J. Racine, H. Chapman, D. Serreze, T. DiLorenzo
This paper develops a mouse model expressing HLA-B*39:06 without murine class I MHC and shows it leads to T1D with reduced thymic insulin expression, despite normal T cell development.
bioRxiv · Feb 13, 2018Immunology