Multiplexed analysis of a single EV (MASEV) reveals unique biomarker composition with diagnostic impact
J. Spitzberg, S. Ferguson, K. Yang, H. Peterson, J. C. T. Carlson, R. Weissleder
The paper introduces MASEV, a method for analyzing single EVs, and finds that common EV markers are rare, biomarkers co-occur in few vesicles, affinity purification loses rare subtypes, and deep profiling improves diagnostic potential.
bioRxiv · Jun 17, 2022 · PreprintCancer Biology