K. Yang

A Drug-Elicitable Alternative-Splicing Module (DreAM) for Tunable AAV Expression and Controlled Myocardial Regeneration

Pro-inflammatory macrophage activation does not require inhibition of mitochondrial respiration

This study shows that reduced oxidative phosphorylation is not required for pro-inflammatory macrophage activation, challenging the conventional model of mitochondrial reprogramming.

Extracellular vesicles-based point-of-care testing for the diagnosis and monitoring of Alzheimer's disease

This paper presents an OECT-based sensor for rapid, sensitive detection of extracellular vesicles in Alzheimer's disease, showing improved sensitivity and reduced detection time.

Mispacking of the F87 sidechain drives aggregation-promoting conformational fluctuations in the subunit interfaces of the transthyretin tetramer

This paper investigates how mispacking of the F87 sidechain in transthyretin tetramers affects conformational dynamics and aggregation propensity through structural and biophysical analyses.

p24-Tango1 interactions ensure ER-Golgi interface stability and efficient transport

The paper investigates Drosophila p24 proteins and finds that their interaction with Tango1 is essential for maintaining ER-Golgi interface stability and efficient transport.

Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats

This study develops a CKD-PH rat model through 5/6 nephrectomy and high-salt diet, showing increased Ang II and RAAS imbalance, ACE2 downregulation, and metabolic changes linked to pulmonary hypertension.

The Arabidopsis PPR protein EMB1006 interacts with both EMB1270 and CFM2 to facilitate plastid clpP1 intron2 splicing

The larva and adult of Helicoverpa armigera use differential gustatory receptors to sense sugars

This study identifies differential gustatory receptors in the larvae and adults of Helicoverpa armigera that enable them to sense sugars differently based on their feeding habits.

An Azapeptide Platform in Conjunction with Covalent Warheads to Uncover High-Potency Inhibitors for SARS-CoV-2 Main Protease

This study develops an azapeptide platform with covalent warheads to identify potent SARS-CoV-2 MPro inhibitors, including MPI89 with a 10 nM EC50 and high selectivity.

Long-B prokaryotic Argonaute systems employ various effectors to confer immunity via abortive infection

The paper identifies long-B prokaryotic Argonaute systems as cell suicide mechanisms that use effector proteins to eliminate invading nucleic acids through abortive infection.

Continuous optical detection of small-molecule analytes in complex biomatrices

This paper introduces an optical biosensor system for continuous detection of biomarkers in complex samples, achieving high sensitivity and long-term monitoring of dopamine and cortisol.

Homeostatic control of an iron repressor in a GI tract resident

The paper shows that Hap43, an iron-responsive transcription factor, is degraded under high iron conditions in C. albicans, leading to antioxidant gene activation and enhanced gut colonization.

VHL Mutation Drives Human Clear Cell Renal Cell Carcinoma Progression Through PI3K/AKT-Dependent Cholesteryl Ester Accumulation

This study identifies VHL mutation as a driver of CE accumulation in ccRCC through the PI3K/AKT pathway, showing that inhibiting cholesterol esterification suppresses tumor aggressiveness.

DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression

This study identifies DUSP6 as a driver of leukemic progression and resistance to JAK2 inhibition in MPNs, highlighting the DUSP6-RSK1 axis as a therapeutic target.

Canonical and Replicable Multi-Scale Intrinsic Connectivity Networks in 100k+ Resting-State fMRI Datasets

The paper develops a reliable network template and methods to estimate individualized functional networks from resting-state fMRI data across 100k+ individuals, showing how data length and spatial resolution affect network estimation.

Destabilized 3UTR ARE therapeutically degrades ERBB2 in drug-resistant ERBB2+ cancer models

The paper develops a method to degrade ERBB2 mRNA and protein by destabilizing its 3UTR AU-rich elements, showing efficacy in drug-resistant cancer models.

Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the pre-hairpin intermediate of the spike protein

Multiplexed analysis of a single EV (MASEV) reveals unique biomarker composition with diagnostic impact

The paper introduces MASEV, a method for analyzing single EVs, and finds that common EV markers are rare, biomarkers co-occur in few vesicles, affinity purification loses rare subtypes, and deep profiling improves diagnostic potential.

The Nucleocapsid Protein Of SARS-CoV-2, Combined With ODN-39M, Is A Potential Component For An Intranasal Bivalent Pancorona Vaccine

This paper evaluates a bivalent intranasal vaccine candidate combining SARS-CoV-2 N protein and ODN-39M, showing cross-reactive immunity against SARS-CoV-1 and enhanced Th1 response when combined with RBD.

Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology

The paper develops an ex vivo 3D microtissue model of MPNST that captures genomic diversity and predicts in vivo drug response.

Interfered Chromosome Pairing Promotes Meiosis Instability of Autotetraploid Arabidopsis by High Temperatures

This study shows that increased temperatures disrupt meiotic stability in autotetraploid Arabidopsis by interfering with chromosome pairing and crossing-over.

The N-Terminal Carbamate is Key to High Cellular and Antiviral Potency for Boceprevir-Based SARS-CoV-2 Main Protease Inhibitors

This paper identifies that a P4 N-terminal carbamate in boceprevir-based inhibitors is crucial for high antiviral potency against SARS-CoV-2.

The P3 O-Tert-Butyl-Threonine is Key to High Cellular and Antiviral Potency for Aldehyde-Based SARS-CoV-2 Main Protease Inhibitors

This study identifies O-tert-butyl-threonine at the P3 site as critical for enhancing cellular and antiviral potency of MPro inhibitors.

Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

Early-life microbial intervention reduces colitis risk promoted by antibiotic-induced gut dysbiosis

The paper shows that adding a specific Bacteroides strain early in life reduces colitis risk in genetically susceptible mice with antibiotic-induced gut dysbiosis.

TMT-based proteomic analysis of the antibiotic effects of ShangKeHuangShui against Straphylococcus aureus.

This study uses TMT-based proteomics to analyze the antibacterial effects of YACTH against Staphylococcus aureus, identifying 490 differentially expressed proteins and their biological pathways.

Wireless endovascular nerve stimulation with a millimeter-sized magnetoelectric implant

This paper introduces a millimeter-sized wireless implant for endovascular nerve stimulation, demonstrating its ability to target peripheral nerves with minimal invasiveness and reduced risk compared to traditional methods.

Land-surface evapotranspiration derived from a first-principles primary production model

The paper develops an evapotranspiration model based on eco-evolutionary principles, showing good agreement with observed data across multiple sites.

Expression of extracellular Hsp90 is a molecular signature of T cell activation, providing a means to image and target T Cell activation in autoimmune disease

This study identifies eHsp90 as a marker of T cell activation, showing its upregulation in autoimmune diseases and demonstrating the efficacy of an inhibitor in delaying disease progression.

Mechanistic Insights of High Temperature-Interfered Meiosis in Autotetraploid Arabidopsis thaliana

This study investigates how high temperatures affect meiosis in autotetraploid Arabidopsis thaliana, revealing that heat stress disrupts chromosome axis stability and meiotic recombination.