S. Ferguson

Four centuries of commercial whaling eroded 11,000 years of population stability in bowhead whales

This study uses fossil data and modeling to show that commercial whaling caused genetic diversity loss in bowhead whales, threatening their resilience to future climate change.

Lysosomal TBK1 Responds to Amino Acid Availability to Relieve Rab7-Dependent mTORC1 Inhibition

The paper identifies TBK1's role in lysosomal signaling, showing it phosphorylates Rab7 to relieve mTORC1 inhibition in response to amino acids.

Stabilisation of soil organic matter with rock dust partially counteracted by plants

This study investigates how rock dust application affects soil organic matter stabilization and carbon sequestration, finding that plants reduce the effectiveness of rock dust by altering cation levels.

Linking movement and dive data to prey distribution models: new insights in foraging behaviour and potential pitfalls of movement analyses

This study links movement and dive data of ringed seals to prey distribution models, finding that movement is not related to foraging effort and seals forage more in areas with lower prey diversity and biomass.

Multiplexed analysis of a single EV (MASEV) reveals unique biomarker composition with diagnostic impact

The paper introduces MASEV, a method for analyzing single EVs, and finds that common EV markers are rare, biomarkers co-occur in few vesicles, affinity purification loses rare subtypes, and deep profiling improves diagnostic potential.

Intracellular Calcium links Milk Stasis to Lysosome Dependent Cell Death by Activating a TGFbeta3/TFEB/STAT3 Pathway Early during Mammary Gland Involution

The paper shows that intracellular calcium, triggered by milk stasis, activates STAT3 via SOCS3 degradation and TFEB, leading to lysosome-dependent cell death during mammary gland involution.

Scaled-expansion of the membrane associated cytoskeleton requires conserved kinesin adaptors

The paper identifies kinesin adaptors that mediate spectrin transport and lattice expansion during axon stretch-growth.

Cytotoxicity mechanisms and composition of the glyphosate formulated herbicide RangerPro

The paper tests the cytotoxicity of RangerPro, a glyphosate-based herbicide, and identifies POE-15 tallow amine as a toxic component in human intestinal cells.

Genomic constraints to drought adaptation

The paper uses genomic and climate data to identify adaptation constraints in Corymbia calophylla, finding that genetic diversity and epistatic interactions limit drought adaptation potential.

Assessing spatial segregation of beluga whales (Delphinapterus leucas) in Western Hudson Bay estuaries

The paper examines spatial distribution of beluga whales by age class in Western Hudson Bay estuaries, finding no segregation between groups with and without calves.

Surf4 Promotes Endoplasmic Reticulum Exit of the Lysosomal Prosaposin-Progranulin Complex

The paper identifies Surf4 as critical for ER exit of the progranulin-prosaposin complex, revealing a mechanism for lysosomal delivery of these proteins.

Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids

This study identifies a peptide motif-mediated interaction between WDR41 and PQLC2 that regulates lysosomal complex recruitment in response to cationic amino acid availability.

JIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton

This study shows that JIP3 depletion disrupts axonal cytoskeleton organization and causes lysosome accumulations in human neurons, linking lysosome transport to cytoskeletal regulation.

Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons

This study investigates the roles of JIP3 and JIP4 in axonal lysosome transport using human iPSC-derived neurons, showing their involvement in preventing lysosome accumulation and amyloid-beta production.

Killer whale genomes reveal a complex history of recurrent admixture and vicariance

This study uses killer whale genomes to reveal complex population history with recurrent admixture and vicariance, showing genetic homogenization at lower latitudes and differentiation at high latitudes.