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J. Tillinghast

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Biophysics· 1

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Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

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D. Bowser· 1 shared K. P. K. Lee· 1 shared

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2021-2021 · peak 1/yr

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D. Bowser

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BiophysicsbioRxivMay 26, 2021

Structural mechanisms for gating and ion selectivity of the human polyamine transporter ATP13A2

J. Tillinghast, D. Bowser, K. P. K. Lee

This study presents three structures of the Parkinson's disease-associated polyamine transporter ATP13A2, revealing its gating mechanism and ion selectivity principles.

DOI 10.1016/j.molcel.2021.10.002

humancryo-EM