Cancer BiologybioRxiv
Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4α and SIX1/4
S. A. Camolotto, V. Belova, L. Torre-Healy…·E. Snyder
This study shows HNF4α suppresses PDAC growth and promotes the Classical subtype by repressing SIX1/4, which are critical for Basal-like subtype proliferation.