Author

R. Moffitt

Stony Brook University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

A PiscontiiD· 1 shared A. Cardenas· 1 shared A. Klochkova· 1 shared A. L. Massa· 1 shared A. M. O'Reilly· 1 shared A. Mazitova· 1 shared A. P. Makohon-Moore· 1 shared B. Curry· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperCell Biology

A PiscontiORCID

Author profile →

4 papers

Recent·Most cited

Enhancement of Prednisolone efficacy and safety in Duchenne muscular dystrophy via neutrophil elastase inhibition

K.A. Johnson, Fiona K. Jones, Rachel S. Ghadiali, G. Lee, L.A. Torre-Healy, M.D. Sweeney, R. Moffitt, Kamel Mamchaoui, E. Ricci, I. Young, A Pisconti

This paper shows that combining Alvelestat with Prednisolone improves muscle function and reduces side effects in a DMD mouse model.

bioRxiv · Feb 26, 2025 · PreprintCell Biology

Pancreatic cancer prognosis is predicted by a novel ATAC-array technology for assessing chromatin accessibility

S. Dhara, S. Chhangawala, H. Chintalapudi, G. Askan, V. Aveson, A. L. Massa, L. Zhang, A. P. Makohon-Moore, N. Lecomte, J. P. Melchor, J. Bermeo, A. Cardenas, S. Sinha, D. Glassman, R. Nicolle, , S. D. Leach

The paper develops ATAC-Array, a low-cost chromatin accessibility assay, and shows it predicts pancreatic cancer prognosis based on chromatin accessibility patterns.

bioRxiv · Jan 21, 2021Cancer Biology

Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4α and SIX1/4

S. A. Camolotto, V. Belova, L. Torre-Healy, J. Vahrenkamp, K. Berrett, H. Conway, C. Stubben, R. Moffitt, J. Gertz, E. Snyder

This study shows HNF4α suppresses PDAC growth and promotes the Classical subtype by repressing SIX1/4, which are critical for Basal-like subtype proliferation.

bioRxiv · Oct 22, 2019Cancer Biology

Cholesterol deprivation induces TGFβ signaling to promote basal differentiation in pancreatic cancer

L. G. Cornell, S. Peri, D. Restifo, A. Klochkova, T. R. Hartman, A. M. O'Reilly, R. Francescone, J. Franco-Barraza, N. Shah, E. Nicolas, E. A. Handorf, K. Q. Cai, A. Mazitova, I. Sloma, R. Chiaverelli, , I. Astsaturov

The paper shows that cholesterol deprivation activates TGFβ signaling, promoting basal differentiation in pancreatic cancer by stabilizing the TGFβ receptor.

bioRxiv · May 11, 2019 · PreprintCancer Biology