E. Snyder

Patho-transcriptomic analysis of invasive mucinous adenocarcinoma of the lung (IMA): comparison with lung adenocarcinoma with signet ring cell features (SRCC)

This study compares the patho-transcriptomic profiles of invasive mucinous adenocarcinoma (IMA) and adenocarcinoma with signet ring cell features (SRCC), identifying distinct and shared gene expression patterns and potential therapeutic targets.

A Lung Cancer Mouse Model Database

The paper establishes a database of lung cancer mouse models to improve data comparison and translational relevance by aligning mouse mutations with human lung cancer mutations.

Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer

This study shows that combining ULK1/2 inhibition with KRASG12C inhibitors reduces lung cancer growth in preclinical models.

FoxA1/2-dependent epigenomic reprogramming drives lineage switching in lung adenocarcinoma

This study shows FoxA1/2 reprogram the epigenome of NKX2-1-negative lung adenocarcinoma to drive a gastric lineage switch through DNA demethylation and regulatory element activation.

Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4α and SIX1/4

This study shows HNF4α suppresses PDAC growth and promotes the Classical subtype by repressing SIX1/4, which are critical for Basal-like subtype proliferation.