NK cells acquire epigenetic memory of LPS-induced systemic inflammation
O. Rasid, C. Chevalier, T. Camarasa, C. Fitting, J.-M. Cavaillon, M. A. Hamon
This study shows that NK cells develop epigenetic memory of LPS-induced inflammation, marked by an H3K4me1 enhancer at the ifng locus, leading to heightened IFN-gamma production upon re-stimulation.
bioRxiv · Dec 25, 2018Immunology