M. A. Hamon

Shigella generates distinct IAM subpopulations during epithelial cell invasion to promote efficient intracellular niche formation

This study identifies distinct IAM subpopulations during Shigella invasion that facilitate BCV disassembly through SNX8 and RAB11A recruitment.

Epithelial cells maintain memory of prior infection with Streptococcus pneumoniae through di-methylation of histone H3

This study shows that S. pneumoniae infection induces persistent H3K4me2 in epithelial cells, altering their transcriptional response to future infections.

Streptococcus pneumoniae drives specific and lasting Natural Killer cell memory

This study shows that NK cells develop specific and long-term memory after Streptococcus pneumoniae infection, enhancing their cytotoxic response and providing protection against future infections.

Pneumococcus uses COMMD2 to alter host cellular immunity.

This study identifies COMMD2 as a bacterial factor that interacts with p65 and p62 to degrade p65, altering host cellular immunity during pneumococcal infection.

The histone demethylase KDM6B fine-tunes the host response to Streptococcus pneumoniae.

This study shows that KDM6B modulates the host response to Streptococcus pneumoniae by altering chromatin structure at the IL-11 promoter, affecting NF-κB activation.

Streptococcus pneumoniae infection promotes histone H3 dephosphorylation by modulating host PP1 phosphatase

This study shows Streptococcus pneumoniae infection causes histone H3 dephosphorylation at serine 10 via host PP1 phosphatase activation, enhancing bacterial survival.

NK cells acquire epigenetic memory of LPS-induced systemic inflammation

This study shows that NK cells develop epigenetic memory of LPS-induced inflammation, marked by an H3K4me1 enhancer at the ifng locus, leading to heightened IFN-gamma production upon re-stimulation.