THUMPD2 catalyzes N2-methylation on the spliceosome catalytic center of U6 snRNA and regulates pre-mRNA splicing
W.-Q. Yang, J.-Y. Ge, X.-F. Zhang, L. Lin, W.-Y. Zhu, Y.-G. Shi, B. Xu, R.-J. Liu
This study identifies THUMPD2 as the methyltransferase responsible for N2-methylation of U6 snRNA at G72, showing it regulates pre-mRNA splicing and cell proliferation.
bioRxiv · Jun 17, 2023 · PreprintBiochemistry