L. Lin

A minimal two-residue C-terminal truncation of AID in adult-onset hyper-IgM syndrome type 2 (HIGM2)

This study identifies a two-residue C-terminal truncation variant in AID causing adult-onset HIGM2 and shows it disrupts CSR and SHM.

Super-Enhancer Driven ZFP36L1 Promotes PD-L1 Expression in Infiltrative Gastric Cancer

This study identifies ZFP36L1, driven by a super-enhancer, as a key regulator of PD-L1 expression in infiltrative gastric cancer, contributing to immune escape.

Synergically enhanced anti-tumor immunity of in vivo CAR by circRNA vaccine boosting

This study develops circRNA-based in vivo CAR and vaccines that synergistically enhance anti-tumor immunity in mice.

MT-125 Inhibits Non-Muscle Myosin IIA and IIB, Synergizes with Oncogenic Kinase Inhibitors, and Prolongs Survival in Glioblastoma

The nuclear speckles protein SRRM2 is a new therapeutic target molecule on the surface of cancer cells

The paper identifies SRRM2 as a surface-exposed cancer target and shows its utility in CAR-T cell therapy.

Complementing Muscle Regeneration: Fibro-Adipogenic Progenitor and Macrophage-Mediated Repair of Elderly Human Skeletal Muscle

This study identifies fibro-adipogenic progenitors and macrophages as key players in elderly human skeletal muscle regeneration through spatial and single-cell transcriptomics, revealing their interplay via complement factor C3.

Generative Modelling of Oncogene-carrying Extrachromosomal Circular DNA Biogenesis and Dynamics in Cells

The paper develops a method to generate oncogene-carrying ecDNAs in human cells and studies their expression and stability under different conditions.

FLASH Irradiation Regulates IFN-β induction by mtDNA via Cytochrome c Leakage

This study shows FLASH irradiation increases cytochrome c leakage from mitochondria in normal cells, reducing mtDNA accumulation and IFN-β secretion, while having the opposite effect in cancer cells.

Tuft cells act as regenerative stem cells in the human intestine

The paper identifies four human tuft cell states, showing they function as radiation-resistant stem cells capable of regenerating the intestinal epithelium.

Prevalent fast evolution of genes involved in heterochromatin functions

The paper investigates the evolutionary dynamics of genes involved in heterochromatin functions in Drosophila, finding they evolve faster than Polycomb-based repressive chromatin genes.

Assessment of the Histone Mark-based Epigenomic Landscape in Human Myometrium at Term Pregnancy

This study maps the epigenomic landscape of human myometrium at term pregnancy, identifying enhancers and regulatory elements associated with PGR and PLCL2.

Contrasting Phyllosphere Mycobiome in two Lycopodiaceae Plant Species: Unraveling Potential HupA-Producing Fungi and Fungal Interactions

This study compares the mycobiome of two Lycopodiaceae species, identifying potential HupA-producing fungi and their interactions in Huperzia asiatica.

Data-driven system matrix manipulation enabling fast functional imaging and intra-image nonrigid motion correction in tomography

This paper introduces methods to improve tomographic imaging by compressing system matrices and correcting motion artifacts, demonstrating improvements in 3D photoacoustic computed tomography.

Lithocholic acid targets TULP3 to activate sirtuins and AMPK to retard ageing

This study identifies LCA's mechanism of action through TULP3-sirtuin-v-ATPase-AMPK pathway to activate AMPK and extend lifespan in model organisms.

Reduced Monocyte Proportions and Responsiveness in Convalescent COVID-19 Patients

This study shows that SARS-CoV-2 infection reduces monocyte subsets and their functional responses in convalescent patients compared to uninfected controls.

Leukemia circulation kinetics revealed through blood exchange method

This study uses a blood exchange method in mouse leukemia models to show that leukemia cells circulate longer than solid tumor cells and that microenvironmental factors like E-selectin influence their clearance.

African bush pigs exhibit porous species boundaries and appeared in Madagascar concurrently with human arrival

This study analyzes whole genomes of African bushpigs and Malagasy bushpigs, revealing recent divergence and gene flow, challenging species boundaries and linking their arrival in Madagascar to human migration.

THUMPD2 catalyzes N2-methylation on the spliceosome catalytic center of U6 snRNA and regulates pre-mRNA splicing

This study identifies THUMPD2 as the methyltransferase responsible for N2-methylation of U6 snRNA at G72, showing it regulates pre-mRNA splicing and cell proliferation.

Latitudinal scaling of aggregation with abundance and its consequences for coexistence in species rich forests

The paper examines latitudinal patterns in species aggregation and abundance, showing how these patterns affect coexistence in forests and introduces a framework to model their impact on extinction risk.

COP9 signalosome complex subunit-7-mediated regulation of cAMP levels contributes to autophagic degradation and pathogenesis of rice blast fungus Magnaporthe oryzae

This study identifies MoCSN7's role in regulating cAMP levels, autophagy, and pathogenesis in Magnaporthe oryzae through functional characterization of COP9 signalosome subunits.

Decomposing intraspecific phenotypic variation: implications for species and functional diversity

The paper investigates intraspecific phenotypic variation in a tropical seedling community, finding alternative phenotypes and their environmental interactions influence growth and species co-occurrence.

MYSM1 co-activates ERα action via histone and non-histone deubiquitination to confer antiestrogen resistance in breast cancer

This study identifies MYSM1 as an ER co-activator that promotes antiestrogen resistance in breast cancer through histone and non-histone deubiquitination.

Investigation of a mathematical model describing global cancer growth and treatment: An inhomogeneous model based on the generalized logistic equation

This paper introduces an inhomogeneous mathematical model based on the generalized logistic equation to describe tumor growth and treatment, validated against clinical observations and theories of tumor heterogeneity.

Persistent gene flow suggests an absence of reproductive isolation in an African antelope speciation model

The paper sequenced waterbuck genomes to study speciation, finding historical gene flow across a Rift Valley barrier and no reproductive isolation.

Vascular endothelial growth factor A contributes to the increasing of mammalian respiratory epithelial permeability induced by Pasteurella multocida infection

This study shows that P. multocida infection increases respiratory epithelial permeability in mice and humans by activating the HIF-1 and VEGFA signaling pathways.

Soil depth governs microbial community assembly and enzymatic activity in extreme environments

The paper examines how soil depth influences microbial community structure and enzymatic activity in extreme desert environments, finding that depth-related environmental heterogeneity drives these patterns.

Type 17 Follicular Helper T (Tfh17) Cells are Superior for Memory Maintenance

This study shows that Tfh17 cells are more effective than Tfh1 and Tfh2 cells in maintaining memory responses after vaccination.

ADOLESCENT EXPOSURE TO LOW-DOSE THC DISRUPTS ENERGY BALANCE AND ADIPOSE ORGAN HOMEOSTASIS IN ADULTHOOD

This study shows that adolescent exposure to low-dose THC leads to metabolic changes in adulthood, including reduced fat mass and adipose dysfunction.

Porous microneedle patch with sustained exosome delivery repairs severe spinal cord injury

This study develops a microneedle patch that delivers mesenchymal stem cell-derived exosomes to treat spinal cord injury, showing improved tissue recovery and functional outcomes in rats.

Rab7/Retromer-based endolysosomal trafficking facilitates effector secretion and host invasion in rice blast

This study identifies a novel endolysosomal trafficking pathway in Magnaporthe oryzae that facilitates effector secretion and host invasion via Rab7/Retromer/MoSnc1-mediated vesicle transport.