Knockout of Bbs10 results in lack of cone electrical function and progressive retinal degeneration of rods and cones
Sara K. Mayer, Jacintha Thomas, Megan Helms, Aishwarya J. Kothapalli, Ioana Cherascu, Adisa Salesevic, Elliot Stalter, Kai Wang, Poppy Datta, Charles C. Searby, Seongjin Seo, Ying Hsu, Sajag Bhattarai, Val C. Sheffield, Arlene V. Drack
This study develops a BBS10 knockout mouse model to investigate retinal degeneration, finding progressive loss of cone function and thinning of the outer nuclear layer.
Disease Models & Mechanisms · Sep 1, 2022Peer-reviewedGenetics