Myeloid-Specific Thrombospondin-1 Deficiency Exacerbates Aortic Rupture via Broad Suppression of Extracellular Matrix Proteins
Ting Zhou, Huan Yang, Carmel Assa, Elise DeRoo, Jack Bontekoe, Brian Burkel, Suzanne Ponik, Hong S. Lu, Alan Daugherty, Bo Liu
This study shows that myeloid-specific thrombospondin-1 deficiency increases aortic rupture risk by suppressing extracellular matrix proteins and inflammation in aneurysms.
bioRxiv · Jul 30, 2024 · PreprintPathology