Upstream open reading frame inactivation augments GATA4 translation and cardiomyocyte hypertrophy in mice
Omar M. Hedaya, Feng Jiang, Uday K. Baliga, Aleksandr Ivanov, Si Chen, Jack L. Schwartz, Yui Kawakami, Yan Chen, Peng Yao
This study shows that inactivating a uORF in the Gata4 gene in mice leads to increased GATA4 translation and cardiac hypertrophy.
bioRxiv · May 18, 2025 · PreprintBiochemistry