Feng Jiang

This study shows that inactivating a uORF in the Gata4 gene in mice leads to increased GATA4 translation and cardiac hypertrophy.

This study shows that loss of EPRS1 in cardiomyocytes causes dilated cardiomyopathy and heart failure, with altered protein homeostasis and metabolic pathways.

The paper identifies dsRNA structures in uORFs that regulate translation and shows ASO targeting can modulate mORF translation and reduce cardiac hypertrophy.

This study identifies PRRC2B as an RNA binding protein that regulates translation of specific mRNAs, including cell cycle regulators, and inhibits cell proliferation by affecting G1/S phase transition.

This study compares the performance of BGI and Illumina sequencing technologies for single-cell RNA-sequencing, finding that BGI outperforms Illumina in cell and gene detection but similar in gRNA detection.

This study demonstrates the use of catalytically inactive CasE fused with split-Fp as a tool for background-free tracking of single RNA in living cells.