The genomic trajectory of ovarian high grade serous carcinoma is determined in STIC lesions
Zhao Cheng, Darren P. Ennis, Bingxin Lu, Hasan Mirza, Chishimba Sokota, Baljeet S. Kaur, Naveena Singh, Olivia Le Saux, Giorgia Russo, Gaia Giannone, Laura A. Tookman, Jonathan Krell, Chris P. Barnes, Jackie McDermott, Iain A. McNeish
This study shows that high ploidy and whole genome duplication in ovarian high-grade serous carcinoma originate in STIC lesions, indicating early determination of the tumor's genomic trajectory.
The Journal of Pathology · Jul 2, 2024Peer-reviewedCancer Biology