Darren P. Ennis

This study uses spatial transcriptomics to compare gene expression in ovarian clear cell carcinoma and adjacent endometriosis across UK and Japanese patients, finding distinct transcriptional patterns by tissue compartment rather than geographic origin.

This paper introduces a dual-view oblique plane microscope for high-resolution imaging of thick cleared tissue samples across multiple species.

The paper identifies two divergent structural variation trajectories in HGSOC that impact patient survival and reveals novel candidate driver genes and mtDNA mutations associated with prognosis.

PolSpec uses polarisation optics to enable rapid, flexible, and cost-effective hyperspectral imaging with reduced data volume.

This study identifies vinorelbine as a compound that enhances the efficacy of a GM-CSF-armed oncolytic vaccinia virus in treating ovarian cancer in mice.

This study shows that high ploidy and whole genome duplication in ovarian high-grade serous carcinoma originate in STIC lesions, indicating early determination of the tumor's genomic trajectory.

This study identifies HMOX1-expressing omental macrophages as a therapeutic target and biomarker for poor prognosis ovarian high-grade serous carcinoma.

FrenchFISH improves DNA copy number quantification from FISH images by using Poisson models, outperforming manual and automated methods in ovarian cancer tissue sections.