Appearance of Amyloid-β Early in Life Initiates Neuronal Hyper-excitability, Mitochondrial Decay, and Loss of Dendritic Complexity in the Hippocampal CA1 Region of 5xFAD Mice
Amanda Kelley, Emily Denise Sackinger, Mathew Frischman, Nicholas O. Thomas, Kaitlyn Kim, Grace Scuderi, Edwin M. Labut, Duncan MacMurchy, Toren Ikea-Mario, Jacob Rauenhorst, Easton Neitzel, Tacita Vu, Leda Liko, Alexandra Hoff, Ashley Hoff, , Tory M. Hagen
This study identifies early synaptic and metabolic dysfunctions in 5xFAD mice before plaque formation, linking them to hippocampal vulnerability in Alzheimer's disease.
bioRxiv · Feb 6, 2026 · PreprintNeuroscience