NeurosciencebioRxivPreprint
Appearance of Amyloid-β Early in Life Initiates Neuronal Hyper-excitability, Mitochondrial Decay, and Loss of Dendritic Complexity in the Hippocampal CA1 Region of 5xFAD Mice
Amanda Kelley, Emily Denise Sackinger, Mathew Frischman…·Tory M. Hagen
This study identifies early synaptic and metabolic dysfunctions in 5xFAD mice before plaque formation, linking them to hippocampal vulnerability in Alzheimer's disease.
DOI 10.64898/2026.02.04.703883