Concordance between male- and female-specific GWAS results helps define underlying genetic architecture of complex traits
Anna K. Miller, Jacquelaine Bartlett, Calvin Pan, Aldons Jake Lusis, Dana C. Crawford, Scott M. Williams, David A. Buchner
The paper uses sex-stratified analyses to explore genetic architecture of complex traits in mice and humans, finding high concordance in allelic effect directions and suggesting new methods for identifying biologically significant associations.
Nature Communications · Sep 30, 2025Peer-reviewedGenetics