Li Wang

Cardiomyocyte-specific loss of Smyd5 leads to a robust activation of inflammatory signaling and heart failure in mice.

This study shows that loss of Smyd5 in cardiomyocytes causes inflammation and heart failure in mice by reducing H4K20me3 and increasing Il-6 expression.

Tyrosine phosphorylation and dimerization cooperatively activate NAMPT to enable NAD+ synthesis in cancer

This study identifies tyrosine phosphorylation and dimerization as cooperative mechanisms activating NAMPT, enhancing NAD+ synthesis and cancer cell growth.

Single-cell lineage tracing of human neuromesoderm organoids reveals TBX6-mediated posterior mesoderm fate diversification

The paper uses single-cell lineage tracing and multiomics profiling to map human neuromesoderm differentiation, revealing TBX6's role in posterior mesoderm fate diversification.

A vascular chip for disease-relevant flow shear stress topology

This paper introduces a vascular chip that enables controlled experimentation with disease-relevant wall shear stress topology, revealing its effects on endothelial mechanics and function.

Low-intensity vibration (LIV) cellular mechanotherapy reprograms tumor transcriptomes to suppress cancer-promoting inflammation

This study shows that low-intensity vibration (LIV) reprograms tumor transcriptomes to suppress cancer-promoting inflammation by modulating cytokines and miRNAs.

Population and community responses to the fast, slow, and seasonal components of environmental variation

The paper examines how different environmental fluctuation components affect macroinvertebrate communities and finds that slow fluctuations have stronger trait-mediated effects than seasonal or fast fluctuations.

DINOcell: Learning Generalizable Perturbation Effects through Self-Distillation

DINOcell predicts cellular responses to perturbations using self-distillation in single-cell transcriptomics, outperforming baselines for single and combination gene effects.

Paclitaxel Alleviates Pulmonary Arterial Hypertension by Modulating Macrophage M2a Polarization via the NF-κB Pathway

This study shows paclitaxel reduces pulmonary arterial hypertension by inhibiting M2a macrophage polarization through the NF-κB pathway in a rat model.

Volumetric Differences of Thalamic Nuclei are Associated with Post-Trauma Psychopathology

The paper examines thalamic volume differences in trauma-exposed individuals with PTSD, MDD, and controls, finding specific volume reductions and associations with symptom severity and childhood trauma.

MEK inhibition induces AXIN1 loss in colorectal cancer by mTOR associated suppression of protein synthesis

This study shows MEK1/2 inhibitors reduce AXIN1 levels in CRC by mTOR-dependent translational repression, not by affecting protein stability.

Nervous system-wide single-cell morphology atlas of excitatory and inhibitory neurons in larval zebrafish

The paper creates a comprehensive atlas of larval zebrafish neuron morphology, including excitatory and inhibitory identities and connectivity patterns.

Cellular and molecular mechanism for reproductive capacity of male Mongolian cattle basing on single-cell sequencing for testis

The paper uses scRNA-seq to analyze testis cell heterogeneity in Mongolian cattle, identifying key cell clusters and genes involved in spermatogenesis and reproductive capacity.

Enrichment of halogenated organic compounds and their degrading microorganisms in the deepest ocean

This study identifies high concentrations of halogenated organic compounds in the Mariana Trench and shows trench microbes actively degrade them through dehalogenation.

Reduced expression of PER2 protein contrbutes to β1-AA induced cardiac autophagy rhythm disorder

This study shows that β1-AA disrupts cardiac autophagy rhythm by reducing PER2 protein expression, which promotes mTORC1 activation and inhibits autophagy in cardiomyocytes.

Pexidartinib plus FLT3-directed CAR-Macrophage for the treatment of FLT3-ITD-mutated acute myeloid leukemia in preclinical model

This study shows that combining pexidartinib with FLT3-directed CAR-macrophages reduces leukemic burden and improves survival in FLT3-ITD+ AML xenograft models.

Predictive Prioritization of Enhancers Associated with Pancreas Disease Risk

The paper develops a method to prioritize enhancers linked to pancreas disease risk by integrating chromatin interactions, machine learning, and single-cell perturbation assays.

Widely dispersed clonal expansion of multi-fungicide-resistant Aspergillus fumigatus limits genomic epidemiology prospects

This study links triazole-resistant A. fumigatus isolates from environmental hotspots to clinical cases of aspergillosis, showing widespread clonal expansion that limits genomic epidemiology's ability to trace infection sources.

Receptor-ligand interactions in plant inmate immunity revealed by AlphaFold protein structure prediction

The paper uses AlphaFold to predict protein structures and identify direct receptor-ligand interactions in plant innate immunity involving R genes and avirulence genes.

Establishment of Transgenic Fluorescent Mice for Screening Synaptogenic Adhesion Molecules

This paper develops transgenic mice expressing tdTomato-fused synaptotagmin 1 to label synapses, enabling efficient screening of synaptogenic molecules without immunostaining.

Extraordinary preservation of gene collinearity over three hundred million years revealed in homosporous lycophytes

This study presents genome assemblies of two homosporous lycophytes, revealing preserved gene collinearity and slow genome evolution over 350 million years.

Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics

This study identifies G9a's noncanonical role in promoting translation of genes involved in hyperinflammation and lymphopenia in COVID-19, revealing therapeutic targets that counteract viral effects.

The role of intestine in metabolic dysregulation in murine Wilson disease

This study investigates the role of the intestine in metabolic dysregulation in murine Wilson disease by analyzing gut microbiota and lipidome in mouse models.

Mapping Transcriptomic Vector Fields of Single Cells

The paper introduces dynamo, a framework for estimating RNA velocities and predicting cell fates using single-cell RNA-seq data, applied to various biological processes.

Episodic memory in aspects of brain information transfer by resting-state network topology

This study investigates the information transfer mechanism of episodic memory using resting-state network topology and task-evoked activity, finding key networks involved in encoding and retrieval processes.

Genomic features of BRDT binding sites in gene units suggest transcriptional partners and specific epigenetic landscapes to regulate transcriptional activity during spermatogenesis

The paper identifies BRDT binding sites in gene units during spermatogenesis and links them to specific transcription factors and epigenetic features that regulate gene expression.

A novel mapping strategy utilizing mouse chromosome substitution strains identifies multiple epistatic interactions that regulate complex traits

This study uses mouse chromosome substitution strains to identify both additive and epistatic genetic loci influencing complex traits and gene expression.

Defining the transcriptional landscape of infiltrating immune cells in human and mouse bladder cancer.

This study maps immune cell transcriptional profiles in human and mouse bladder tumors to identify conserved and divergent gene expression patterns and immune cell interactions.

Molecular and cellular heterogeneity of gastric cancer explained by methylation-driven key regulators

The paper identifies 11 methylation-driven key regulators in gastric cancer and shows they contribute to tumor heterogeneity and clinical outcomes.

Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion

The paper uses scATAC-seq to analyze chromatin accessibility in immune cell development and tumor microenvironments, identifying regulatory elements and trajectories associated with cell differentiation and therapy response.

Endothelial cells secreted ET-1 augments DN via inducing EM accumulation of MCs in ETBR-/- mice

This study shows ET-1 secreted by endothelial cells in ETBR-/- mice worsens diabetic nephropathy by promoting mesangial cell proliferation and ECM accumulation through NF-kappaB and RhoA/ROCK pathways.