Disruption of the Wnt-antagonist Apc in the pituitary stem cells drives the development of adamantinomatous craniopharyngioma.
James Blackburn, Laura Gomez-Corral, James Nicholson, Ashutosh Rai, Jingyi Xue, Rachael Tan, Kalyana C. Gangaraju, Angelica Gualtieri, Charlotte Louise Hall, Pinaki R Dutta, Márta Korbonits, Federico Roncaroli, Shannon William Davis, Carles Gaston‐Massuet
This study shows that disrupting Apc in pituitary stem cells causes adamantinomatous craniopharyngioma (aCP) in mice, independent of β-catenin mutations, and identifies Sox2+ stem cells as the cell of origin.
bioRxiv · Sep 28, 2025 · PreprintCancer Biology