CDKL5 deficiency impairs TBK1-mediated autophagy and clearance of neuronal protein aggregates
Zhongju Zou, Bilal Kahn, Salwa Sebti, Jason Lucavs, Giomar Rivera‐Cancel, Josephine W. Thinwa
This study identifies a CDKL5/SINTBAD/TBK1 signaling pathway that regulates autophagy and protein aggregate clearance in neurons, showing that CDKL5 deficiency impairs this process.
bioRxiv · Sep 18, 2026 · PreprintPhysiology