Innate immune sensing of cell traversal by Plasmodium sporozoites drives protective T cell responses
Kai G. Pohl, Xin Gao, Jason McGowan, Parnika Mukherjee, Shirley Le, Patricia Eugenia Carreira, Chinh Ngo, Henry J. Sutton, Sophia Brumhard, Anna Luisa Hiller, Hannah G. Kelly, Larissa Liow, Adrian F. Lo, Larissa Henze, Lucie Loyal, , Ian Andrew Cockburn
The paper shows that Plasmodium sporozoites trigger innate immune responses via cell traversal, which is essential for activating protective CD8+ T cells.
Nature Microbiology · Sep 30, 2026Peer-reviewedImmunology