Author

Jayesh Shah

Columbia University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1

Frequent Co-Authors

Michael T. YiniD· 5 shared Lawrence J. PurpuraiD· 4 shared Anthony D. BoweniD· 3 shared Aubree L. GordoniD· 3 shared Carmen GherasimiD· 3 shared David D. HoiD· 3 shared Ian A. MellisiD· 3 shared Madeline Wu· 3 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersMicrobiology

Michael T. YinORCID

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Author profile →

5 papers

Recent·Most cited

Distinct CD8+ T-cell types Associated with COVID-19 Severity in Unvaccinated HLA-A2+ Patients

Kazuya Masuda, Sho Iketani, Lihong Liu, Jing Huang, Yujie Qiao, Jayesh Shah, Meredith McNairy, Christine Groso, Christopher L. Ricupero, Lucas F. Loffredo, Qian Wang, Lawrence J. Purpura, Jordana Grazziela Alves Coelho-dos-Reis, Zizhang Sheng, Michael T. Yin, Moriya Tsuji

The paper identifies distinct CD8+ T-cell types associated with mild versus severe COVID-19 in unvaccinated HLA-A2+ patients, showing protective immunity correlates with specific cell subsets.

bioRxiv · Jun 19, 2026Immunology

Antibody evasion and receptor binding of SARS-CoV-2 LP.8.1.1, NB.1.8.1, XFG, and related subvariants

Ian A. Mellis, Madeline Wu, Hsiang Hong, Chih-Chen Tzang, Anthony D. Bowen, Qian Wang, Carmen Gherasim, Virginia Pierce, Jayesh Shah, Lawrence J. Purpura, Michael T. Yin, Aubree L. Gordon, Yicheng Guo, David D. Ho

This study compares antibody evasion and receptor binding of SARS-CoV-2 subvariants, finding that LP.8.1.1 has high ACE2 affinity, while NB.1.8.1 and XFG show greater antibody evasion.

Cell Reports · Nov 24, 2025Peer-reviewedMicrobiology

Do Existing COVID-19 Vaccines Need to Be Updated in 2025?

Ian A. Mellis, Madeline Wu, Qian Wang, Anthony D. Bowen, Carmen Gherasim, Riccardo Valdez, Jayesh Shah, Lawrence J. Purpura, Michael T. Yin, Aubree L. Gordon, Yicheng Guo, David D. Ho

This study assesses whether 2025 COVID-19 vaccines need updating by testing neutralizing antibody titers against emerging variants in individuals vaccinated with KP.2-based mRNA vaccines.

bioRxiv · May 2, 2025 · PreprintMicrobiology

KP.2-based monovalent mRNA vaccines robustly boost antibody responses to SARS-CoV-2

Qian Wang, Ian A. Mellis, Madeline Wu, Anthony D. Bowen, Carmen Gherasim, Riccardo Valdez, Jayesh Shah, Lawrence J. Purpura, Michael T. Yin, Aubree L. Gordon, Yicheng Guo, David D. Ho

This study evaluates KP.2-based monovalent mRNA vaccines and finds they robustly boost neutralizing antibodies against current SARS-CoV-2 variants, including KP.3.1.1 and XEC.

The Lancet Infectious Diseases · Feb 4, 2025Peer-reviewedMicrobiology

A First-in-Class Dual Degrader of Bcl-2/Bcl-xL Reverses HIV Latency and Eliminates Ex Vivo Reservoirs

Lin-Chun Chang, Michael T. Yin, Gregory M. Laird, Kristen D. Ritter, Jayesh Shah, Asim Kumar Debnath

This paper demonstrates that PZ703b, a dual Bcl-2/Bcl-xL degrader, reverses HIV latency and reduces the replication-competent reservoir in ex vivo CD4+ T cells from ART-suppressed patients.

bioRxiv · Oct 16, 2024 · PreprintMolecular Biology