HER2; p53 Co-mutated Cancers Show Increased Histone Acetylation and are Sensitive to Neratinib plus Trastuzumab Deruxtecan.
Xiaoqing Cheng, Jacob Hsia, Jesus Iraheta, Joanna M. Gongora, Maureen K. Highkin, Xiaohua Jin, Zhanfang Guo, Julie L. Prior, John R. Edwards, Shunqiang Li, Ian S. Hagemann, Cynthia X. Ma, Zongtao Lin, Benjamin A. Garcia, Ron Bose
This study shows that HER2 and TP53 co-mutant cancers have increased histone acetylation and are sensitive to neratinib plus trastuzumab deruxtecan.
bioRxiv · Jul 6, 2025 · PreprintCancer Biology