Author
Washington University in St. LouisORCID 0000-0002-8156-7492Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Xiaoqing Cheng, Jacob Hsia, Jesus Iraheta…·Ron Bose
This study shows that HER2 and TP53 co-mutant cancers have increased histone acetylation and are sensitive to neratinib plus trastuzumab deruxtecan.
Michael D. Iglesia, Reyka G. Jayasinghe, Siqi Chen…·Li Ding
This study identifies breast cancer subtypes and their lineage origins by analyzing chromatin accessibility and transcriptional dynamics using multi-omic techniques.
Shunqiang Li, Tina M. Primeau, Maureen K. Highkin…·Ron Bose
The paper tests neratinib combinations with T-DM1 and vinorelbine in HER2 mutated breast cancer PDX models and organoids, finding synergistic effects that could inform clinical trials.
Sam Crowl, Ben T. Jordan, Hamza Ahmed…·Kristen M. Naegle
KSTAR predicts patient-specific kinase activities from phosphoproteomic data, improving comparison across labs and identifying tissue-specific profiles and treatment responses.