Prompting Beyond Pairs: Decoupled Semantic Supervision for Knowledge-Guided Multiplex Virtual Staining
Yuqi Hu, Jiahao Wang, Kexiao Zheng, Yeying Jin, Hanry Yu
This paper introduces a semantic supervision method for virtual staining that replaces pixel-level supervision with domain knowledge prompts, enabling high-fidelity synthesis of subcellular structures from single-channel data.
bioRxiv · Sep 4, 2026 · PreprintBioengineering